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mitotane will lessen the level or effect of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of abemaciclib with sturdy CYP3A4 inducers minimizes plasma concentration of abemaciclib and its metabolites.You might have the injections in the clinic or at your GP surgery. Your GP, s